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Find information for healthcare professionals about Rituxan® (rituximab), the only FDA-approved treatment proven to induce remission in patients with GPA and MPA. INDICATION STATEMENT - Rituxan® (rituximab), in combination with glucocorticoids, is indicated for the treatment of adult patients with Granulomatosis with Polyangiitis (GPA) (Wegener’s Granulomatosis) and Microscopic Polyangiitis (MPA) - Limitations of Use: Rituxan is not recommended for use in patients with severe, active infections BOXED WARNINGS and Additional Important Safety Information BOXED WARNINGS Infusion Reactions: Rituxan administration can result in serious, including fatal, infusion reactions. Deaths within 24 hours of Rituxan infusion have occurred. Approximately 80% of fatal infusion reactions occurred in association with the first infusion. Monitor patients closely. Discontinue Rituxan infusion for severe reactions and provide medical treatment for Grade 3 or 4 infusion reactions. Severe Mucocutaneous Reactions: Severe, including fatal, mucocutaneous reactions can occur in patients receiving Rituxan. Hepatitis B Virus (HBV) Reactivation: HBV reactivation can occur in patients treated with Rituxan, in some cases resulting in fulminant hepatitis, hepatic failure, and death. Screen all patients for HBV infection before treatment initiation, and monitor patients during and after treatment with Rituxan. Discontinue Rituxan and concomitant medications in the event of HBV reactivation. Progressive Multifocal Leukoencephalopathy (PML): PML, including fatal PML, can occur in patients receiving Rituxan. Warnings and Precautions Rituxan administration can also result in additional serious, including fatal, adverse reactions including: - Tumor lysis syndrome (TLS): Administer aggressive intravenous hydration, anti‑hyperuricemic agents, monitor renal function - Infections: Withhold Rituxan and institute appropriate anti-infective therapy - Cardiac arrhythmias and angina: Discontinue infusions in case of serious or life-threatening events - Bowel obstruction and perforation: Consider and evaluate for abdominal pain, vomiting, or related symptoms - Live virus vaccines: Do not administer live virus vaccines prior to or during Rituxan - Cytopenias: Monitor blood counts at regular intervals Granulomatosis With Polyangiitis (GPA) (Wegener’s Granulomatosis) and Microscopic Polyangiitis (MPA) - Use of concomitant immunosuppressants other than corticosteroids has not been studied in GPA or MPA patients exhibiting peripheral B-cell depletion following treatment with Rituxan. Observe patients with GPA and MPA closely for signs of infection if immunosuppressants other than corticosteroids are used concomitantly - The safety and efficacy of retreatment with Rituxan have not been established in patients with GPA and MPA - Common adverse reactions (≥15%) in the clinical study were infections, nausea, diarrhea, headache, muscle spasms, anemia, and peripheral edema. Other important adverse reactions include infusion reactions You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555. For additional safety information, please see the Rituxan full prescribing information, including BOXED WARNINGS.

Ehlers Danlos Syndrome (EDS) is a heterogeneous group of heritable connective tissue disorders, characterized by articular (joint) hypermobility, skin extensibility and tissue fragility. Ehlers-Danlos Syndrome (EDS) is a group of inherited disorders that affect connective tissue. The body's connective tissues binds and supports the body's muscles, ligaments, organs and skin. EDS is characterized by articular (joint) There are six major types of EDS. The different types of EDS are classified according to their manifestations of signs and symptoms. Each type of EDS is a distinct disorder that "runs true" in a family. This means that an individual with Vascular Type EDS will not have a child with Classical Type EDS. Individuals with EDS have a defect in their connective tissue, the tissue which provides support to many body parts such as the skin, muscles and ligaments. The fragile skin and unstable joints found in EDS are the result of faulty collagen. Collagen is a protein which acts as a "glue" in the body adding strength and elasticity to connective tissue.

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Gasoline Advertising Products is a leading manufacturer of the fuel dispenser price signs, pump graphic, decals, signs and image upgrade products for fueling stations and convenience store industry. GAP manufacturers and distribute quality products in range of wide variety at reasonable cost right here in the United States of America. GAP is also a leading provider of advertising signage, DOT signage, safety and compliance signage in petroleum market. We also provide products and services to Trucking and fuel carrier companies as well as AST and UST Tank and environmental company.

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Laser Lab India manufacturers, distributors, service, spares & accessories providers, for Laser machines for laser engraving, laser cutting, laser marking systems, Aesthetic, Beauty, Cosmetic , Lipo & LLLT lasers for Body Shaping, Inch Loss, Weight Reduction, Stretch Marks Reduction, Pain Rrelief & Healing, using Nd-YAG, CO2, DPSS, diode pumped, lamp pumped laser sources, hi power lasers, pin marking and engraving machines, for different applications for automotive, engineering, garment, fashion, architacture, gift and signage, macheniry manufacturing industries. Distributors of world's leading Laser companies in India like Epilog Laser, VGen, Laservall, Rofin Sinar, Precision Machineries, Precision CNC Equipment Co., Photograve, GTPE, Wavelength, etc.

MiLEOX is the revolutionary formulation that removes signs of wrinkle with its anti-aging products from sheep placenta extracts products to tomato stem cells products. The new simple way to look younger and beautiful using MiLEOX anti-wrinkle products.

Pancreatic cancer often has a poor prognosis, even when diagnosed early. There are rarely symptoms in the early stages of cancer of the pancreas. Find in-depth information on pancreatic cancer including adenocarcinoma of the pancreas, neuroendocrine, islet-cell, and carcinoid tumors